“MagQu” Phosphorylated Tau protein [pT181] IMR Reagent

  • Catalog No. MF-PT1-0060
  • For rapid quantifying phosphorylated Tau protein (p-Tau181) by Immuno Magnetic Reduction (IMR).
  • Quantify phosphorylated Tau protein (p-Tau181) in the sample easily, rapidly, and accurately
  • Magnetic Nanoparticle
  • Dextran layer
  • For Alzheimer’s disease research and for in-vitro diagnosis use

Intended Use

“MagQu” Phosphorylated Tau protein [pT181] IMR Reagent  is used to quantitatively measure phosphorylated Tau protein(p-Tau181) in human fluid specimen, such as plasma, serum or CSF.

Use “MagQu” Phosphorylated Tau protein [pT181] IMR Reagent only with the XacPro-S System (MagQu Co., Ltd.). 


Tau protein is a microtubule-associated protein and is abundant in nervous system. Tau protein can maintain the structure of neuron cells and support the transport of substance. When tau proteins phosphorylated, It will result in the self-assembly of tangles in brain and increased some neurodegenerative diseasesincluding Alzheimer’s disease (AD)、Pick's disease、Parkinson's disease (PD)、Progressive supranuclear palsy(PSP) and Corticobasal degeneration (CBD). The phosphorylated Tau protein at position threonine 181 (p-Tau181) is more specific for disease progression (from mild cognitive impairment to Alzheimer's disease)1

Principles of Test

“MagQu” Phosphorylated Tau protein [pT181] IMR Reagent is designed for rapid quantifying phosphorylated Tau protein(p-Tau181) by Immuno Magnetic Reduction (IMR). We conjugated the antibody on the surface of around 50 nm-in-diameter Fe3O4 magnetic particles. When the antibodies on the surface bind with phosphorylated Tau protein (p-Tau181), the magnetic particles form clusters. Therefore, the ac susceptibility (Xac) of magnetic particles would be reduced in the adding ac magnetic field. By measuring the reduction of Xac, we can quantify phosphorylated Tau protein(p-Tau181) in the sample easily, rapidly, and accurately.2,3


1. E.S. Blom, V. Giedraitis, H. Zetterberg, H. Fukumoto, K. Blennow, B.T. Hyman, M.C. Irizarry, L.O. Wahlund, L. Lannfelt, M. Ingelsson,"Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype", Dement Geriatr Cogn Disord. 27(5):458-64. 2009.
2. C.Y. Hong, C.C. Wu, Y.C. Chiu, S.Y. Yang, H.E. Horng, H.C. Yang, "Magnetic susceptibility reduction method for magnetically labeled immunoassay", Appl. Phys. Lett. , 88, 212512-1–212512- 3, 2006.
3. C.C. Yang, S.Y. Yang, C. S. Ho, et al., "Development of antibody functionalized magnetic nanoparticles for the immunoassay of carcinoembryonic antigen: a feasibility study for clinical use" J Nanobiotechnology. 12: 44. 2014.
Iron Oxide (Fe3O4)
Surface protein
Anti-phosphorylated Tau protein(p-Tau181) antibody
Mean Diameter of Particles
50 ~ 60 nm
The analytical range of reagent
0.019569 to 100 pg/mL phosphorylated Tau protein(p-Tau181)
Storage temp.
2 ~ 8 ℃
Ordering information:
Catalog Number Description Package Size
MF-PT1-0060 48 tests 1 mL x 4
  • Applications Content: 
    Quantitative detection for ultra-low-concentration bio-molecules, e.g. Alzheimer's-disease bio-markers in blood.