“MagQu” Phospho-α-Synuclein IMR Reagent

  • Catalog No. MF-PS1-0060
  • For rapid quantifying phosphorylated α-synuclein(p-ASC129) by Immuno Magnetic Reduction (IMR).
  • Quantifying Phosphorylated α-synuclein(p-ASC129) in the sample easily, rapidly, and accurately
  • Magnetic Nanoparticle
  • Dextran layer
  • For Parkinson’s disease (PD) research and for in-vitro diagnosis use

Intended Use

“MagQu” Phospho-α-Synuclein IMR Reagent is used to quantitatively measure phosphorylated α-synuclein (p-ASC129) in human fluid specimen, such as plasma, serum or CSF.

Use “MagQu” Phospho-α-Synuclein IMR Reagent only with the XacPro-S System (MagQu Co., Ltd.). 


Parkinson’s disease (PD) is characterized by the intraneuronal α-synuclein inclusions called Lewy bodies. Increase of phosphorylation of α-synuclein in Serine 129 (p-ASC129) has been correlated with the aggregation, toxicity, protein interaction and turnover of α-synuclein. Thus, p-ASC129 can indicate the pathogenesis of PD.1,2

Principles of Test

“MagQu” Phospho-α-synuclein IMR Reagent is designed for rapid quantifying phosphorylated α-synuclein (p-ASC129) by ImmunoMagnetic Reduction (IMR). We conjugate antibody on the surface of around 50 nm-in-diameter Fe3O4 magnetic particles. When the antibodies on the surface bind with phosphorylated α-synuclein (p-ASC129), the magnetic particles form clusters. Therefore, the ac susceptibility (Xac) of magnetic particles would be reduced in the adding ac magnetic field. By measuring the reduction of Xac, phosphorylated α-synuclein (p-ASC129) can be easily, rapidly and accurately quantified.3


1. Wang, Y., Shi, M., Chung, K. A., Zabetian, C. P., Leverenz, J. B., Berg, D., Srulijes, K., Trojanowski, J. Q., Lee, V. M., Siderowf, A. D., Hurtig, H., Litvan, I., Schiess, M. C., Peskind, E. R., Masuda, M., Hasegawa, M., Lin, X., Pan, C., Galasko, D., Goldstein, D. S., Jensen, P. H., Yang, H., Cain, K. C., Zhang, J. (2012). Phosphorylated α-synuclein in Parkinson's disease. Science translational medicine, 4(121), 121ra20.

2. Oueslati A. (2016). Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?. Journal of Parkinson's disease, 6(1), 39-51.

3.C.C. Yang, S.Y. Yang, C. S. Ho, et al, ”Development of antibody functionalized magnetic nanoparticles for the immunoassay of carcinoembryonic antigen: a feasibility study for clinical use.”, Journal of Nanobiotechnology, 2014, 12:44.


Iron Oxide (Fe3O4)
Surface protein
Anti-phosphorylated α-Synuclein(p-ASC129) antibody
Mean Diameter of Particles
50 ~ 60 nm
The analytical range of reagent
0.00048 to 0.4826 pg/mL phosphorylated α-Synuclein(p-ASC129)
pH 7.4 PBS
Storage temp.
2 ~ 8 ℃
Ordering information:
Catalog Number Description Package Size
MF-PS1-0060 64 tests 1 mL x 4
  • Applications Content: 
    Quantitative detection for ultra-low-concentration bio-molecules, e.g. Parkinson’s disease bio-markers in blood.