“MagQu” Neurofilament light IMR Reagent

  • Catalog No. MF-NFL-0060
  • For rapid quantifying Neurofilament light by Immuno Magnetic Reduction (IMR).
  • Quantify NfL in the sample easily, rapidly, and accurately
  • Magnetic Nanoparticle
  • Dextran layer
  • For Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington disease (HD) research and for in-vitro diagnosis use

Intended Use

“MagQu” Neurofilament light IMR Reagent is used to quantitatively measure neurofilament light(NfL) in human fluid specimen, such as plasma, serum or CSF.

Use “MagQu” Neurofilament light IMR Reagent only with the XacPro-S System (MagQu Co., Ltd.).


Neurofilament light(NfL) is a specific cytoskeletal protein highly expressed in largely myelinated axons. Increased levels of NfL in CSF and blood are clinically useful biomarkers in many neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington disease (HD). 1,2

Principle of Test

“MagQu” Neurofilament light IMR Reagent is designed for rapid quantifying NfL by ImmunoMagnetic Reduction (IMR). We conjugate antibody on the surface of around 50 nm-in-diameter Fe3O4 magnetic particles. When the antibodies on the surface bind with NfL, the magnetic particles form clusters. Therefore, the ac susceptibility (Xac) of magnetic particles would be reduced in the adding ac magnetic field. By measuring the reduction of Xac, NfL can be easily, rapidly and accurately quantified.3


1. Lewczuk, P., Ermann, N., Andreasson, U., Schultheis, C., Podhorna, J., Spitzer, P., Maler, J. M., Kornhuber, J., Blennow, K., Zetterberg, H. (2018). Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer's disease. Alzheimer's research & therapy, 10(1), 71. doi:10.1186/s13195-018-0404-9

2. Hansson, O., Janelidze, S., Hall, S., Magdalinou, N., Lees, A. J., Andreasson, U., Norgren, N., Linder, J., Forsgren, L., Constantinescu, R., Zetterberg, H., Blennow, K., Swedish BioFINDER study (2017). Blood-based NfL: A biomarker for differential diagnosis of parkinsonian disorder. Neurology, 88(10), 930-937.

3. C.C. Yang, S.Y. Yang, C. S. Ho, et al., "Development of antibody functionalized magnetic nanoparticles for the immunoassay of carcinoembryonic antigen: a feasibility study for clinical use" J Nanobiotechnology. 12: 44. 2014.


Iron Oxide (Fe3O4)
Surface protein
Anti-Neurofilament light antibody
Mean Diameter of Particles
50 ~ 60 nm
The analytical range of reagent
0.01 to 100 pg/mL neurofilament light protein
pH 7.4 PBS
Storage temp.
2 ~ 8 ℃
Ordering information:
Catalog Number Description Package Size
MF-NFL-0060 64 tests 1 mL x 4
  • Applications Content: 
    Quantitative detection for ultra-low-concentration bio-molecules, e.g. Alzheimer’s disease, Parkinson’s disease, Huntington disease bio-markers in blood.