Product

“MagQu” Tau Protein Control Solution-H

  • Catalog No. CL-TAU-050T
Features:
  • For Immuno Magnetic Reduction (IMR)
Description

Tau protein is a microtubule-associated protein (MAP) and is abundant in nervous system. It can maintain the structure of neuron cells and support the transport of substance. The self-assembly tangles of Tau protein are loss-of-function and result in total Tau protein increase in many neurodegenerative diseases such as Alzheimer’s disease (AD) 、Pick's disease、 Parkinson's disease (PD)、Progressive supranuclear palsy (PSP) and Corticobasal degeneration (CBD).1, 2

Tau Protein Control Solution is used as a standard control for “MagQu” Tau protein IMR Reagent (MF-TAU-0060). The antibody conjugated on the surface of Fe3O4 magnetic particles (~ 50 nm) could bind with Tau protein and form clusters. With the increase of cluster, the signal of ac susceptibility ( χac ) will decrease in the applied ac magnetic field. That is the principle of Immuno Magnetic Reduction (IMR). By measuring the reduction of χac , we can quantify the Tau protein in the sample easily and accurately.3

 

References

  1. M.J. Chiu, S.Y. Yang, T.F. Chen, J.J. Chieh, T.Z. Huang, P.K. Yip, H.C. Yang, T.W. Cheng, Y.F. Chen, M.S. Hua, and H.E. Horng, “New assay for old markers-plasma beta amyloid of mild cognitive impairment and Alzheimer’s Disease”, Curr. Alzheimer Res. 9, 1142 (2012).
  2. M.J. Chiu, Y.F. Chen, T.F. Chen, S.Y. Yang, F.P. Gloria Yang, T.W. Tseng, J.J. Chieh, J.C. Rare Chen, K.Y. Tzen, M.S. Hua, and H.E. Horng, “Plasma tau as a window to the brain-negative associations with brain volume and memory function in mild cognitive impairment and early alzheimer's disease”, Human Barin Mapping, 15 Oct. (2013).
  3. Che-Chuan Yang, Shieh-Yueh Yang, Jen-Jie Chieh, Herng-Er Horng, Chin-Yih Hong, Hong-Chang Yang, K. H. Chen, B. Y. Shih, Ta-Fu Chen, and Ming-Jang Chiu, “Biofunctionalized magnetic nanoparticles for specifically detecting biomarkers of Alzheimer’s disease in vitro”, ACS Chem. Neurosci. 2, 500 (2011).
Specification:
Form
Liquid
Color
Colorless
pH-value at 20℃ (68 °F)
7.4
Storage temp
Shipped at 4°C. Store at -15°C~-30°C
Ordering information:
Catalog Number Description Package Size
CL-TAU-050T 25 tests 1 mL
Applications:
  • Applications Content: 
    For Immuno Magnetic Reduction (IMR)