首頁

“MagQu” Phospho-α-Synuclein(pS129) IMR Reagent

  • Catalog No. MF-PS1-0060
  • For rapid quantifying Phospho-α-synuclein(pS129) by Immuno Magnetic Reduction (IMR).
產品特色:
  • Quantifying Phospho-α-synuclein(pS129) in the sample easily, rapidly, and accurately
  • Magnetic Nanoparticle
  • Dextran layer
  • For Parkinson’s disease (PD) research and for in-vitro diagnosis use
產品描述

Parkinson’s disease (PD) is characterized by the intraneuronal α-synuclein inclusions called Lewy bodies. Increase of phosphorylation of α-synuclein in Serine 129 (S129) has been correlated with the aggregation, toxicity, protein interaction and turnover of α-synuclein. Thus, S129 can indicate the pathogenesis of PD.1,2

The “MagQu” Phospho-α-synuclein IMR Reagent is designed for rapid quantifying phosphorylated α-synuclein (S129) by ImmunoMagnetic Reduction (IMR). We conjugate antibody on the surface of around 50 nm-in-diameter Fe3O4 magnetic particles. When the antibodies on the surface bind with phosphorylated α-synuclein (S129), the magnetic particles form clusters. Therefore, the ac susceptibility (Xac) of magnetic particles would be reduced in the adding ac magnetic field. By measuring the reduction of Xac, phosphorylated α-synuclein (S129) can be easily, rapidly and accurately quantified.

 

References

  1. Wang, Y., Shi, M., Chung, K. A., Zabetian, C. P., Leverenz, J. B., Berg, D., Srulijes, K., Trojanowski, J. Q., Lee, V. M., Siderowf, A. D., Hurtig, H., Litvan, I., Schiess, M. C., Peskind, E. R., Masuda, M., Hasegawa, M., Lin, X., Pan, C., Galasko, D., Goldstein, D. S., Jensen, P. H., Yang, H., Cain, K. C., Zhang, J. (2012). Phosphorylated α-synuclein in Parkinson's disease. Science translational medicine, 4(121), 121ra20.
  2. Oueslati A. (2016). Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?. Journal of Parkinson's disease, 6(1), 39-51.
產品規格:
Core
Iron Oxide (Fe3O4)
Layer
Dextran
Surface protein
Anti-p-α-Synuclein antibody
Mean Diameter of Particles
50 ~ 60 nm
The analytical range of reagent
0.00048 to 48.26 pg/mL p-α-synuclein protein
Buffer
pH 7.4 PBS
Storage temp.
2 ~ 8 ℃
訂購資訊:
型號 產品描述 包裝規格
MF-PS1-0060 65 tests 1 mL x 4
產品應用:
  • Applications Content: 
    Quantitative detection for ultra-low-concentration bio-molecules, e.g. Parkinson’s disease bio-markers in blood.