神經細胞內的α-突觸核蛋白內含物是巴金森氏症(Parkinson’s disease, PD)的特徵之一，並稱之為路易氏體(Lewy bodies)。α-突觸核蛋白第129個胺基酸-絲胺酸(S129)的磷酸化，會提高α-突觸核蛋白的聚集性、毒性、蛋白質交互作用與代謝。因此S129能顯示巴金森氏症的致病機轉。^{1, 2}

“磁量”磷酸化α-突觸核蛋白品管液做為“磁量”磷酸化α-突觸核蛋白免疫磁減量檢測試劑(MF-PS1-0060)的品管材料。其檢測原理為當磁珠表面的磷酸化α-突觸核蛋白抗體與磷酸化α-突觸核蛋白結合後，磁珠會聚集成較大的分子，使磁珠在外加磁場下產生的磁減量 (χ_ac) 減少。而透過磁減量的變化量，可以簡單、精確地測得磷酸化α-突觸核蛋白的濃度。³

References

1. Wang, Y., Shi, M., Chung, K. A., Zabetian, C. P., Leverenz, J. B., Berg, D., Srulijes, K., Trojanowski, J. Q., Lee, V. M., Siderowf, A. D., Hurtig, H., Litvan, I., Schiess, M. C., Peskind, E. R., Masuda, M., Hasegawa, M., Lin, X., Pan, C., Galasko, D., Goldstein, D. S., Jensen, P. H., Yang, H., Cain, K. C., Zhang, J. (2012). Phosphorylated α-synuclein in Parkinson's disease. Science translational medicine, 4(121), 121ra20.
2. Oueslati A. (2016). Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?. Journal of Parkinson's disease, 6(1), 39-51. 
3. Che-Chuan Yang, Shieh-Yueh Yang, Jen-Jie Chieh, Herng-Er Horng, Chin-Yih Hong, Hong-Chang Yang, K. H. Chen, B. Y. Shih, Ta-Fu Chen, and Ming-Jang Chiu, “Biofunctionalized magnetic nanoparticles for specifically detecting biomarkers of Alzheimer’s disease in vitro”, ACS Chem. Neurosci. 2, 500 (2011).